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The resulting piperazine-linked glucuronide contains a positively charged piperazine amine and is predicted to form an electrostatic interaction with the catalytic acid/base glutamate in the active site (Fig

This resistance to ferroptosis decreases L-ROS but not iron levels (Hayano et al., 2016)

Within the ER, the signal peptide is cleaved, disulfide bonds form, and the peptide is folded

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