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MATERIALS AND METHODS: In cell experiments, human dermal fibroblasts were treated by a series of GHK-Cu and HA combinations, and the expressions of collagen I, IV, and VII were measured by qRT-PCR

Notably, the ionized HS is more reactive than the un-ionized H 2 S and exerts its biological effects through binding electrophiles in a process known as sulfhydration or attaching to other reactive sulfur species (thiols) to form disulfide bonds in a process known as persulfhydration

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MD parameters for AdoCbl and OHCbl have been deposited on Figshare ( Initial and final structures from MD simulations have been deposited on Figshare ( All other source data are provided as supplementary data files