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Lactate shuttling links histone Kla, particularly H4K12la, to neural stem cells (NSCs) proliferation through murine double minute 2 (MDM2)-p53 signaling pathway and eventually regulates cell cycle and endows NSCs neurogenic potential in the adult hippocampus

Only a handful of small studies have been completed, with inconclusive results

For example, the ROCK1/PTEN/PI3K signaling pathway regulates cofilin phosphorylation, mitochondrial translocation, and death of malignant cells

The MAPK signaling pathway is responsible for cell signaling in response to various stimuli, including oxidative stress [85]

Early studies suggest it may be, but long-term research is still ongoing