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The single chain pro-polypeptide is proteolytically processed by convertases to yield a mature a (heavy chain 55 KDa), and (light chain 34 KDa) heterodimer, which are bound together by a disulfide link (Stella and Comoglio, 1999

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In a similar model, rats supplemented with zinc had a significant reduction in opened tight junctions when compared with untreated rats with colitis, but no amelioration of clinical disease [157]

Additionally, these phenolics have a great role in the colon by inhibiting cancer-causing microorganism growth via reducing pH in the fermentation environment (148)