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While Retatrutide treatment generally led to a further downregulation of most mediators in this pathway, it powerfully and selectively upregulated the level of ()15-HETE, increasing it by more than 6-fold compared to the HFD group

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Phytochemistry 67 , 10531067 (2006)

1180 Methotrexate, a csDMARD, diminishes HK2 and GLUT expression in RA FLSs, 1181 and iguratimod disrupts the HIF-1-HK2 axis, compromising Tfh cell function

Glutathione reductase (GR) is a NADPH-dependent oxidoreductase which catalyzes the conversion of oxidized glutathione (GSSG) to reduced glutathione (GSH)