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While GSH is a primary antioxidant in the ELF, SCN is also an important antioxidant at detoxifying HOCl from excess MPO activity and is dependent on CFTR to be exported into the ELF

Ghanian Z, Konduri GG, Audi SH, Camara AKS, Ranji M

Many experimental studies have shown that female mice are less susceptible to APAP hepatotoxicity than males and that the sex differences are substantial [17,18,35]