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The process initiates with radical-induced proton abstraction from deoxyribose, leading to multiple reaction intermediates and ribose fragments through hydrogen atom transfer (HAT) ( 2 forms a sugar peroxyl radical that converts into a hydroperoxide intermediate

Breastfeeding is not recommended during Alimta therapy and for one week after the last dose

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Biochem Biophys Res Commun 183(2):733-8, 1992

CAFs, MCs, ECs, adipocytes, and immune subsets all contribute to a protective and immunosuppressive niche that shields tumor cells from platinum-induced damage