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These metabolites influence the survival and function of neighboring cells within the same environment, thereby establishing bidirectional metabolic communication between T cells and their surroundings

Although not fully understood, calorie restriction is widely recognized to extend longevity and in mice reduces senescent cell burden

The expression of co-stimulatory molecules on DCs, including CD80 and CD86, is notably increased in vitiligo patients (73), enhancing their antigen-presenting ability and promoting the activation and proliferation of T cells, particularly CD8 + T cells, which contribute to the destruction of melanocytes

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