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A drug can be metabolized in the gut wall (eg, by the CYP3A4 enzyme system) or even in the portal blood, but most commonly it is the liver that is responsible for metabolism before the drug reaches the systemic circulation

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The stomach is not resected, so acid and intrinsic factor production are mostly preserved

This is why two formulations at the same stated concentration can produce different research effects

Use teat dip with antiseptic to kill any bacteria that may be on the teats