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Obesity and metabolic dysfunction are also linked with AMD risk, so changing body weight, insulin resistance, lipids, blood pressure, and systemic inflammation could plausibly change eye-risk patterns

With a sample of 1,014 subjects (789 simvastatin users, 225 atorvastatin users) from the Rotterdam study, they reported that the number of dose reduction or statin switching events significantly ( p = 0.045) increased with the number of A alleles

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Medications that alter stomach acid, such as proton pump inhibitors (PPIs) and H2 blockers, as well as the diabetes medication Metformin, can significantly impair the absorption of B12 in the digestive tract