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The regulatory influence of the gut microbiota on pulmonary immune homeostasis has been demonstrated through microbiota transfer (MT) experiments

Giefing-Krll C, Berger P, Lepperdinger G, Grubeck-Loebenstein B

An exciting recent development has been the discovery of itaconate as an anti-inflammatory metabolite which inhibits the succinate-hypoxia-inducible factor-1 axis (Lampropoulou et al., 2016)