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Moreover, MSU relies on ITGB1 on the surface of macrophages to activate the inflammatory signaling pathway, which suggests that targeting and inhibiting integrins on the surface of macrophages to inhibit inflammation in MSU-induced inflammatory complications is one of the research directions for precision therapy

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Zouboulis, Isotretinoin Revisited: Pluripotent Effects on Human Sebaceous Gland Cells, Journal of Investigative Dermatology, Volume 126, Issue 10, 2006, Pages 2154-2156, ISSN 0022-202X, ( 7