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Furthermore, machine learning has been instrumental in predicting novel biomarkers for diagnosis and prognosis linked to lactylation

TB-500 has a more complex structure with a molecular formula of C212H350N56O78S and a molecular weight of 4963.44 g/mol

The high BPA treatment group displayed decreased ER expression (Supplementary Fig

It is well established that triple-negative breast cancer (TNBC) is highly aggressive [22], with significantly higher rates of metastasis and recurrence compared to other breast cancer subtypes [23], especially in isceral and brain metastasis [24]

In particular, these cells highly express the monocarboxylate transporter MCT4 on their plasma membrane, which transports intracellularly accumulated lactate into the microenvironment, accelerating glycolytic flux [41, 42]