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4.3.3 Iron homeostasis disruption Cigarette smoke (CS) perturbs systemic and cellular iron homeostasis through several interconnected mechanisms: (1) Hepcidin Upregulation: CS exposure elevates hepcidin expression, which subsequently downregulates the iron exporter ferroportin (FPN)

FIGURE 3 4.5 Pyroptosis Pyroptosis, a distinct form of programmed cell death, is characterized by cellular swelling leading to membrane rupture, subsequent release of cellular contents, and the initiation of a potent inflammatory response (Zhao et al., 2024)

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TDLNs in immunotherapy TDLNs in anti-cancer immune response In the last decade, the landscape of cancer treatment has undergone significant changes, primarily driven by the progress of immunotherapy