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Transferrin receptor 1 (TfR1), a well-known regulator of cellular iron that internalizes the transferrin-bound iron, plays a significant role in ferroptosis, and ROS induction has been shown to enhance TfR1 protein levels and serves as a marker of ferroptosis 8

Two properties of the sequence were emphasized as unusual for a peptide of that length: its reported stability in human gastric juice and its solubility in water, both of which distinguished it from peptides expected to be rapidly degraded in an acidic proteolytic environment [2]

Key takeaways: The body eliminates harmful substances through a three-phase process

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doi: 10.1158/1078-0432.ccr-23-0430 326 ChenPLiYLiuRXieYJinYWangMet al