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The peptide induces cell death through suppression of survivin expression, a protein that inhibits apoptosis in cancer cells

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Local excision is performed when feasible, as radical resection has not conferred a survival advantage in retrospective studies.[1-3] Optimal excision margins have not been prospectively studied, but the ultimate goal is to obtain negative histological margins.[4] Lymph node management Sentinel lymph node biopsy (SLNB) Lymphatic mapping and SLNB should be considered to assess the presence of occult metastasis in the regional lymph nodes of patients with primary tumors measuring at least 0.8 mm thick with clinically negative nodes

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