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Erastin binds to the xCT-4F2hc complex, where its chlorophenoxy group interacts with the Phe254 residue in xCT TM6b, inhibiting xCT activity, depleting intracellular cysteine and glutathione, and inducing ferroptosis [41]

Zhang L, Wu M, Yu D, Teng Y, Wei T, Chen C, Song W (2018) Identification of glutathione peroxidase (GPX) gene family in Rhodiola crenulata and gene expression analysis under stress conditions

Chua ME, Gnech M, Ming JM, Silangcruz JM, Sanger S, Lopes RI, Lorenzo AJ, Braga LH (2017) Preoperative hormonal stimulation effect on hypospadias repair complications: Meta-analysis of observational versus randomized controlled studies

received research grants from Gilead Science and Pilant Therapeutics

This bacterial defence mechanism has been shown to promote an anti-inflammatory response and induce a disease-tolerant immune response ( Psuedomonas aeruginosa and Staphylococcus aureus utilise itaconate as a carbon source to establish a persistent infection and support the development of biofilms ( Figure 1B )