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[DOI] [PubMed] [Google Scholar] [132].Ferreira TM, Leonel AJ, Melo MA, Santos RR, Cara DC, Cardoso VN, et al

Importantly, the TME does not only surround the tumor cells, it actively contributes to tumor development and progression (47), drug resistance (48), and metastasis (49)

If the research timeline permits using the entire vial within 48 hours of thawing, the remaining potency may still be sufficient depending on dose tolerance in your model