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A systematic search was conducted in the PubMed and Google Scholar databases from January 2000 to September 2024 via the following search terms:"thermal water,""balneotherapy,""cosmetic effect,""balneotherapy,""spa therapy,""antioxidants,""oxidants/reactive oxygen species,""skin diseases,""in vitro studies,"and"in vivo studies"via OR and AND operators

The medication can interfere with the body's ability to absorb calcium and maintain strong bones

Laura McCallister, from the Division of Periodontology (Ohio State University), for her contributions to the logistical support related to this study and for her expert editorial assistance