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Methylated, non-mutated template plasmids were digested with DpnI, and the correct mutation was confirmed via sequencing

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Trends Biochem Sci 41(7):568577 Deguise MO, Pileggi C, De Repentigny Y, Beauvais A, Tierney A, Chehade L, Michaud J, Llavero-Hurtado M, Lamont D, Atrih A, Wishart TM (2021) SMN depleted mice offer a robust and rapid onset model of nonalcoholic fatty liver disease