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Despite the enormous success of the Hib-conjugate vaccine in preventing invasive infections caused by capsular type b H.influenzae , it has no effect on NTHi because these strains lacks the type b capsule (the vaccine target) (Hariadi et al., 2015)

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Disorders affecting the spine include: In NF-1, there can be a generalized abnormality of the soft tissues in the fetus, which is referred to as mesodermal dysplasia, resulting in maldevelopment of skeletal structures