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Vitamin B12 is indispensable for sustaining energy levels, with its deficiency linked to reduced energy production in the body

doi: 10.1111/jphp.12334

Barnham KJ, Masters CL, Bush AI

Recently, non-covalent inhibitors of SmTGR, presenting antischistosomal efficacy in an animal model of infection, were developed targeting the doorstop pocket (here site S3), which further validates this pocket as a druggable site 96

Such models are useful in studying metabolic and developmental consequences of thyroid hormone deficiencies, giving insight into how thyroid hormone insufficiency impacts growth and neurological function