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The sirtuins are NAD + -dependent deacetylases that are distributed in the nucleus (e.g., SIRT1, SIRT6, and SIRT7), the cytoplasm (e.g., SIRT2) and mitochondria (e.g., SIRT3-5), respectively

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[DOI] [Google Scholar] 47.Ding S., Barr J.A., Lyu Z., Zhang F., Wang M., Tieu P., Li X., Engelhard M.H., Feng Z., Beckman S.P., et al

occasional reports of mild headache, transient jitteriness, or injection-site reactions