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Similarly, in a study by Yakisich et al (18), who studied the effect of metformin alone or in combination with 2-DG and WZB on H460 cell viability, a strong synergistic effect was discovered

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Foveolar thickness decreased in 56% of patients (p 3 lines in 50% of eyes after 1 month and in 42% of eyes at last follow up.8 eyes developed recurrent ME at an average of 5.5 months after initial TA injection.Cheng et al.107Prospective nonrandomized interventional comparative study.16 eyes (4 mg TA)

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FIGURE 2 In contrast, with the administration of L-NAME, there was a moderate generalized irregularity in the diameter of blood vessels with moderate atrophy of the optic disc, faint presentation of the choroidal blood vessels appears immediately, and these lesions (Figure 2, IN, IIN) rapidly progress (Figure 3, AC