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The glycolytic enzymes characterized by significantly downregulated transcription upon infection were hexokinase 2 ( HK2 ), glucose6phosphate isomerase ( GPI ), phosphofructokinase liver type ( PFKL ), aldolase fructosebisphosphate C ( ALDOC ), triosephosphate isomerase 1 ( TPI1 ), and enolase 2 ( ENO2 ), thus suggesting a broad downregulation of the glycolytic pathway (Fig 1B)

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Furthermore, we discuss the possible mechanisms involved in the beneficial effects of nutrition on the brain after ES, including neuroinflammation, oxidative stress, hypothalamus-pituitary-adrenal axis regulation and the microbiome-gut-brain axis

As a catalyst, vitamin B12 has a decisive influence on the structure of the genetic material DNA and is necessary for cell structure and energy metabolism