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The effects of RPM on the transcriptome profile during follicular and early embryo were investigated, and the results showed that it is likely that DNA methylation may have been a mechanism utilized to modulate gene expression patterns (Peagaricano et al., 2013)

Cancer 122 , 506516 (2020)

These changes were associated with the upregulation of DRP1-mediated mitochondrial fragmentation and autophagy proteins (Amigo et al., 2017) (Figure 3)

doi: 10.3389/fphar.2025.1718803 Received 04 October 2025 Revised 07 November 2025 Accepted 10 November 2025 Published 26 November 2025 Volume 16 - 2025 Edited by Giuseppe Remuzzi, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Italy Reviewed by Muhammad Saboor, University of Sharjah, United Arab Emirates Ferruh Artunc, University of Tbingen, Germany Updates Copyright 2025 Deng, Gong, Huang, Zhou and Ren