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10.1016/s0009-8981(02)00388-1 70 GonzalesR.AuclairC.VoisinE.GauteroH.DhermyD.BoivinP

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(1997, Journal of Endocrinology) reported that IGF-1 LR3 supported protein turnover in tumor-bearing catabolic rats but also increased tumor growth in that model

Thus, by activating the coagulationinflammation axis, worsening the local microenvironment, promoting urate crystal aggregation, and accelerating tissue fibrosis, hypercoagulability contributes significantly to tophus development and persistence