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A key feature of the inactive state is the presence of a major hydrogen bond network (MHN) involving residues N111 3.35 , N295 7.46 , D74 2.50 and N298 7.49 (superscripts denote BallesterosWeinstein numbering 96 ), which acts as a molecular switch that stabilizes the inactive conformation

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Endometriosis is a common cause of infertility and a medical condition that affects 2 to 10 percent of American women