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Gene set enrichment analysis (GSEA) was performed to identify gene ontology terms and pathways associated with differential gene expression

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Mid-protocol assessment and adjustments 4-6 week evaluation: Assess progress against baseline measurements

Cells treated with test compounds were washed with PBS and incubated with 10 M 2,7-dichlorofluorescein diacetate (DCFH-DA) at 37 C for 30 min, followed by washing with PBS, digestion with trypsin, and collection