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Abstract: In the last two decades, many new peptides have been developed, and new knowledge on how peptides improve the skin has been uncovered

doi: 10.1038/s41467-017-00074-w 22 FavoryJ

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Understanding the underlying causes of these disorders is essential for developing effective treatments and improving the lives of those affected

Anyway, at higher concentrations, like those deriving from a high-fat diet, primary and secondary BAs can reduce gut barrier integrity with their detergent properties, causing increased intestinal permeability and, thus, oxidative stress, DNA damage, and production of inflammatory cytokines, such as IL-6 and TNF-alpha, which promote inflammation and cause the inactivation of the FXR, thereby powering a pro-inflammatory state in the colon [25]