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Specifically, cardiovascular risk factors may mediate at least a part of their effects on the heart and blood vessels via hyperuricemia and the latter may exert their deleterious effects on cardiac and vascular structures via cardiovascular risk factors (notably arterial hypertension)

357,363 In addition, there are mild signs for astrocytic reactivity mainly in cerebral neocortices

Ethics declarations Ethics approval and consent to participate The study was approved by the Hospital 12 de Octubre Ethical Committee (21/580), and all patients and donors provided written informed consent following the Declaration of Helsinki

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This technique is a lifesaver for peptides that are right on the edge of solubility