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Oxidative stress peripheral parameters in Graves disease: the effect of methimazole treatment in patients with and without infiltrative ophthalmopathy

What the clinical evidence shows The landmark Phase 2 trial by Teichman et al

Of note, AMPK has an Akt phosphorylation site on the C terminal domain of the alpha subunit, which, when bound by Akt, modulates the AMPK/LKB1 complex increasing chances of AMPK phosphorylation (Yan et al., 2018[164]), making it a potential therapeutic target