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Cell Biology 27, 14481464

As a result, putrescine-induced GABA levels were reduced in primary cultured hippocampal astrocytes upon genetic ablation of Aldh1a1 as well as Sirt2 (Fig

Furthermore, IHC and IF staining indicated that DMM surgery decreased the expression of Aggrecan and induced pathological MMP13 overexpression, thereby exacerbating extracellular matrix (ECM) metabolism imbalance in OA cartilage