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As the build slowly comes together, it starts to feel less like assembling a collectible and more like revisiting a place you once knew by heart

This affects all SAM-dependent reactions, for example the nerves through reduced production of myelin and acetylcholine but also neurotransmitter synthesis and degradation in the biopterin cycle, as we discussed above

With most drugs in psychiatry, though, short half-lives do not necessarily translate into earlier benefits, and where higher levels need to be attained sooner than can be attained by waiting for 5 half-lives, this is achieved by administering higher initial (loading) doses, or by crowding earlier doses and then spacing them out into the recommended dosing intervals