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Feld 5 , Harel Dahari 1 and Kazuaki Chayama 2,6,7 , (1)The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA, (2)Hiroshima Institute of Life Sciences, (3)R&D, Phoenixbio Co., Ltd., (4)Phoenixbio Co., Ltd., (5)Viral Hepatitis Care Network (VIRCAN), Toronto, Canada, (6)Collaborative Research Laboratory of Medical Innovation, Hiroshima University, (7)Riken Center for Integrative Medical Sciences Background: Understanding of HCV early evolution and the interplay between HCV and the mammalian host will help to identify key aspects of early HCV infection that is crucial for the design of an urgently needed prophylactic HCV vaccine