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The Canadian legislation would give each of the 10 provinces power to set the minimum age, with at least Quebec, Alberta and Manitoba likely to choose the younger option of 18 to match the drinking age

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Safety Monitoring Recommendations Based on the available clinical trial data, clinicians prescribing orforglipron should: (1) counsel patients about expected GI side effects during dose escalation, (2) follow the recommended dose-titration schedule to minimize GI intolerance, (3) monitor for signs of pancreatitis and discontinue if suspected, (4) assess hepatic and renal function at baseline and periodically, (5) screen for personal or family history of MTC or MEN 2, and (6) review concomitant medications for potential CYP3A-mediated drug interactions

However, various challenges are encountered in the use of polyphenols for the treatment of TBIs, which include: i