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Human Trx and GSH systems have compensatory activities so that inhibition of one arm can be supplemented by the other 60 , suggesting that the inhibition of hTrxR by some of the compounds presented here will not be detrimental for humans as it is for schistosomes

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Blank solvent was run after every 10 samples and before and after pooled quality control samples to minimize carry-over effects

For the MTT assay, superoxide dismutase (SOD) activity measurement and determination of H 2 O 2 and NO concentrations, a 96-well plate with a fixed plasma flame was utilized

It exists in every cell and helps neutralize free radicals