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Because the active agent was found circulating in blood, the entire premise from day one was that GHK is a systemic, blood-borne signal rather than a purely local factor

Oksman et al., 2009)

However, potential side effects can include mild gastrointestinal issues or allergic reactions

Conversely, we define Treg exhaustion more specifically as a state induced by chronic inflammation, characterized by persistent expression of inhibitory receptors (e.g., PD-1/TIGIT), metabolic insufficiency, epigenetic and lineage instability (such as FOXP3 destabilization), and a decline in suppressive capacity, particularly in the context of continuous antigenic and cytokine stimulation

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