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The coexistence of MET over-expression and an EGFR T790M mutation is related to acquired resistance to EGFR tyrosine kinase inhibitors in advanced non-small cell lung cancer

Notably, this defect was rescued by expression of wild-type SMC3-GFP but not by the SMC3-KE/KE-GFP mutant, indicating that SMC3 residues mediating Sororin-CTR binding are required for proper cohesion