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Perturbations in mtDNA copy number or mutation burden can trigger metabolic rewiring and epigenetic derangements with lasting effects on gene expression and organismal metabolism, as illustrated by links between embryonic mtDNA depletion, PPAR hypermethylation, and altered lipid homeostasis in adulthood [8, 57, 106]

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However, its important to note that Botox provides temporary results, necessitating maintenance visits to sustain its effects