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Guidelines from the British Committee for Standards in Hematology suggested the use of total serum vitamin B 12 as the first-line test, with MMA as the second-line test (Devalia et al., 12 does not reflect cellular, genetic, and pharmacological disturbances that lead to functional vitamin B 12 deficiency

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This product is intended strictly for scientific research and in-vitro laboratory use only

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However, TREK-1 knockout mice are viable and generally healthy, suggesting that complete loss of TREK-1 function is tolerated