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Clinician insight: oxidative stress markers (F2-isoprostanes, 8-OHdG), mitochondrial assays, and low-grade immune markers are rarely measured despite being early indicators of damage

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However, evidence suggests that this regions distinctive axonal architecture and neuronal activity patterns have profound influence in OLs both locally and along the axons in the corpus callosum (Caldwell et al., 2023)

Collectively, these advances underscore how PBN is propelling MI/R treatment into an era of precision damage control and repair

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