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It is studied in preclinical models to investigate sleep architecture regulation, stress response modulation, HPA axis function, and neuroendocrine interactions

Sixty patients aged 65 and older were randomly assigned to either a loading dose regimen (daily administration for 14 days followed by weekly doses) or a regimen without a loading dose (administration every 3 days) over 90 days

Beyond the anti-necroptotic and anti-inflammatory activities of 6-paradol that play a major role in the preservation of dopaminergic neurons, the current study showed that 6-paradol augmented PPAR/PGC-1/TFAM signaling cascade and mitigated oxidative stress

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