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These results are consistent with the elevated H 2 O 2 in GPX1-deficient hepatocytes promoting the oxidation and inactivation of PTPs and hence insulin signalling and glucose homeostasis

anti-p-IKK/(Ser176/180), Cell Signaling Technology, #2697, for immunoblotting

L-Glutathione (reduced glutathione, GSH) is a naturally occurring tripeptide composed of L-glutamate, L-cysteine, and glycine, joined through an unusual -glutamyl bond