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The reason this stood out for me is because when I looked up Pickart, he has been working on this molecule for decades

At the protein level, R2 expression was more sensitive than expression of R1 to down-regulation upon p53 stabilization (Fig 3D)

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The authors claimed that autophagic flux is decreased, rather than increased, by oxidative stress triggered by exogenous oxidants H 2 O 2

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