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The biotransformations carried out by the microbiota include hydrolysis, oxidation, reduction, and isomerization reactions, which alter the chemical structure, pharmacological activity, and toxicity of TCM compounds, generating new active metabolites

Age-related changes in the number and proliferation of fibroblasts in the human skin

Consider splitting the dose into smaller increments taken throughout the day to prevent acute hepatic saturation

10.1016/j.neurobiolaging.2018.06.038 Neurobiol

An ensuing low-grade thyroid dysfunction has been associated with bipolar disorder and most likely influences both the clinical presentation and the treatment response (179, 180)