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It therefore seems unlikely, although not impossible, that PregS or DHEAS could rapidly associate with a receptor present within the cell without a specific membrane transporter

Fixed schedule regimens typically involve reducing doses over a 3 to 6 day period, and require regular clinical review (minimum of daily) to ensure the patient is not over or under-medicated (Table 8.5 provides an example of a fixed-schedule regimen)

And those numbers are what we need to examine next

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These trials have shown dose-dependent weight loss and improvements in glycemic markers