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Description

Discovery of Second generation reversible covalent DPP1 inhibitors leading to an Oxazepane Amidoacetonitrile based clinical candidate (AZD7986)

doi: 10.1002/med.21599 135 CostaEDRezendeBACortesSFLemosVS

Diethylester derivatives were seen to be more easily delivered into cells ( 2-Oxothiazolidine-4-carboxylic acid (OTC) is hydrolyzed to cysteine in vivo