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In general, ECs are connected side-by-side through transmembrane adhesion proteins [37], including vascular endothelial and neural cadherin at adherent junctions [38, 39], occludin [40], and members of the claudin family [41], as well as the junctional adhesion molecule (JAM) family at tight junctions [42]

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Biological activities (i.e., proliferation/survival/motogenesis) mediated by HGF binding to the c-Met receptor require the active form of HGF

Informal tracking with scattered notes or photos fragments the record and hides patterns during dose increases, making it harder to connect recurring reactions that worsen after two days to specific sites or dose changes