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Phenolic acids such as 3-hydroxybenzoic acid (3-HBA), 3,4-dihydroxybenzoic acid (3,4-diHBA), and 3-(3-hydroxyphenyl)propionic acid (3-HPPA), produced as a consequence of microbial fermentation, interfere with the assembly of monomeric forms of -synuclein into its protofibrils in vitro , and upon administration, improved locomotor activity in an A53T Drosophila model of synucleinopathy ( Bacillus subtilis , a commensal microbe, can inhibit the aggregation of -synuclein in both young and aged Caenorhabditis elegans models of synucleinopathy in varied pathways ( B

For D6 the median IC 50 values in nM units were as follows: CQ, 13.0, n = 14, (Interquartile range (IQR) 5.3 to 18.3), MQ